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http://www.newsmax.com/health/drug_combo_acne/2008/02/12/72014.html
Drug Combo Treats Severe Acne in Women
Tuesday, February 12, 2008
The oral contraceptive Yasmin, plus a low-dose of the diuretic
spironolactone, is a safe and effective treatment for women with severe
facial acne, according to the findings of a small study.
Hormones can play a role in the development of acne. "Several studies have
demonstrated that combined oral contraceptives can be an effective treatment
for acne in women," Dr. Aleksandar Krunic from Northwestern University
Feinberg School of Medicine, Chicago, and colleagues point out in the
Journal of the American Academy of Dermatology.
The researchers therefore examined the safety and efficacy of acne treatment
using both spironolactone and Yasmin -- a combined contraceptive containing
estrogen and a version of progestin called drospirenone - in 27 women with
severe facial acne.
At the end of the study, 11 percent of women were entirely clear of acne
lesions, 74 percent had excellent improvement, 7.4 percent had mild
improvement, and 7.4 percent had no change.
There were no reports of significant weight gain or menstrual cycle
irregularities. There were no side effects severe enough to necessitate
discontinuation of either of the medications.
The combination of spironolactone plus estrogen and drospirenone is
"attractive for control of moderate to severe, hormonally-influenced female
acne," Krunic's team concludes. "However, we recommend that our results be
confirmed with a larger series of patients."
SOURCE: Journal of the American Academy of Dermatology, January 2008.
Drug Combo Treats Severe Acne in Women
Tuesday, February 12, 2008
The oral contraceptive Yasmin, plus a low-dose of the diuretic
spironolactone, is a safe and effective treatment for women with severe
facial acne, according to the findings of a small study.
Hormones can play a role in the development of acne. "Several studies have
demonstrated that combined oral contraceptives can be an effective treatment
for acne in women," Dr. Aleksandar Krunic from Northwestern University
Feinberg School of Medicine, Chicago, and colleagues point out in the
Journal of the American Academy of Dermatology.
The researchers therefore examined the safety and efficacy of acne treatment
using both spironolactone and Yasmin -- a combined contraceptive containing
estrogen and a version of progestin called drospirenone - in 27 women with
severe facial acne.
At the end of the study, 11 percent of women were entirely clear of acne
lesions, 74 percent had excellent improvement, 7.4 percent had mild
improvement, and 7.4 percent had no change.
There were no reports of significant weight gain or menstrual cycle
irregularities. There were no side effects severe enough to necessitate
discontinuation of either of the medications.
The combination of spironolactone plus estrogen and drospirenone is
"attractive for control of moderate to severe, hormonally-influenced female
acne," Krunic's team concludes. "However, we recommend that our results be
confirmed with a larger series of patients."
SOURCE: Journal of the American Academy of Dermatology, January 2008.